福興武術國民中小學國立臺灣體育運動大學競技運動學系2021-04-212025-07-302021-04-212021-04-212226-535Xhttps://ir.ntus.edu.tw/handle/987654321/70227運動員因長期高強度訓練及競賽求勝的壓力而出現過度訓練症候群，不僅危及健康，也會直接影響訓練及競技表現。目前對於過度訓練症候群的評估方法，須同時檢測許多生理生化項目後再做統整分析，耗時、費力且花費高，又因運動員個別差異，出現的症狀不盡相同，常造成判斷上的困難。已有許多研究顯示由細胞分泌至胞外的胞外小泡，其內所含之成分會隨著生理的變化有所不同，因此，可能可做為發炎相關症狀或是疾病惡化程度的臨床診斷指標。本文藉由瞭解近年來對胞外小泡及其在體內對骨骼肌細胞再生、分化調控之影響及機轉的研究，未來可分析運動員進行最大運動後體液中出現的胞外小泡其內容物變化較明顯者，作為評估過度訓練症候群之生物指標，這可提供教練及選手即時的資訊，兼具學術創新性及實務應用性。 Athletes have high risk for overtraining syndromes due to long-term high-intensity training and competition stress. Overtraining syndrome is harmful to health and also negatively affects training and athletic performance. Currently, diagnosis for overtraining syndromes integrates many physiological and biochemical items, which is time consuming, laborious and costly. Moreover, different players may show variable symptoms that made the diagnosis difficult. Many studies have shown that extracellular vesicles are secreted by cells to the extracellular environments and their specific contents are variable depending on the physiological changes. Therefore, the contents of extracellular vesicles may be used as clinical diagnostic indicators of cancer, inflammation-related symptoms or the severity of disease. This article introduced recent studies regarding the effects and mechanisms of extracellular vesicles on the regeneration and differentiation of skeletal muscle cells. In the future, the significantly changed contents of extracellular vesicles from athletes immediately after the maximal exercise may become the biomarkers of overtraining syndromes. Meanwhile, the information will be immediately available to coaches and athletes. Also, this idea is novel academically and has the potential to be applied in training.917801 bytesapplication/pdf胞外小泡; 過度訓練症候群; 生物指標Extracellular Vesicles; Overtraining Syndrome; Biomarkersarticle