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Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-kappa B Signaling Pathway and NLRP3 Inflammasome Activation

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cris.lastimport.scopus2026-02-25T16:02:09Z
dc.creatorHuang, Chi-Han
dc.creatorWang, Shu-Chi
dc.creatorChen, I-Chen
dc.creatorChen, Yi-Ting
dc.creatorLiu, Po-Len
dc.creatorFang, Shih-Hua
dc.creatorHuang, Shu-Pin
dc.creatorYeh, Hsin-Chih
dc.creatorLiu, Ching-Chih
dc.creatorLee, Po-Yen
dc.creatorLi, Chia-Yang
dc.date2021-06
dc.date.accessioned2021-11-08T06:24:04Z
dc.date.accessioned2025-07-27T15:03:16Z
dc.date.available2021-11-08T06:24:04Z
dc.date.issued2021-11-08T06:24:04Z
dc.description.abstractPiplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to examine the anti-inflammatory activities of piplartine in vitro, ex vivo and in vivo using murine J774A.1 macrophage cell line, peritoneal macrophages, bone marrow-derived macrophages and an animal sepsis model. The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE(2), TNF-alpha and IL-6 production, decreases the phosphorylation of MAPKs and NF-kappa B and attenuates NF-kappa B activity by LPS-activated macrophages. Piplartine also inhibits IL-1 beta production and suppresses NLRP3 inflammasome activation by LPS/ATP- and LPS/nigericin-activated macrophages. Moreover, piplartine reduces the production of nitric oxide (NO) and TNF-alpha, IL-6 and IL-1 beta, decreases LPS-induced tissue damage, attenuates infiltration of inflammatory cells and enhances the survival rate. Collectively, these results demonstrate piplartine exhibits anti-inflammatory activities in LPS-induced inflammation and sepsis and suggest that piplartine might have benefits for sepsis treatment.
dc.format.extent103 bytes
dc.format.mimetypetext/html
dc.identifier.doi10.3390/ph14060588
dc.identifier.issn1424-8247
dc.identifier.urihttps://ir.ntus.edu.tw/handle/987654321/64478
dc.languageen_US
dc.publisherBASEL, SWITZERLAND: MDPI
dc.relationPHARMACEUTICALS, 14(6)
dc.subjectpiplartine
dc.subjectmacrophage
dc.subjectinflammation
dc.subjectNLRP3 inflammasome
dc.subjectsepsis
dc.titleProtective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-kappa B Signaling Pathway and NLRP3 Inflammasome Activation
dc.typearticle
dspace.entity.typePublication

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