Publication: Underweight increases the risk of early death in tuberculosis patients
| cris.lastimport.scopus | 2026-02-25T16:02:09Z | |
| dc.creator | Yen, Yung-Feng | |
| dc.creator | Tung, Fu-I | |
| dc.creator | Ho, Bo-Lung | |
| dc.creator | Lai, Yun-Ju | |
| dc.date | 2017-12-28 | |
| dc.date.accessioned | 2021-11-04T08:43:47Z | |
| dc.date.accessioned | 2025-07-28T15:04:21Z | |
| dc.date.available | 2021-11-04T08:43:47Z | |
| dc.date.issued | 2021-11-04T08:43:47Z | |
| dc.description.abstract | Evidence regarding the association between BMI and mortality in tuberculosis (TB) patients is limited and inconsistent. We investigated the impact of BMI on TB-specific and non-TB-specific mortality with respect to different timing of death. All Taiwanese adults with TB in Taipei were included in a retrospective cohort study in 2012-2014. Multinomial Cox proportional hazards regression was used to evaluate the associations between BMI, cause-specific mortality and timing of death. Of 2410 eligible patients, 86.0 % (2061) were successfully treated, and TB-specific and non-TB-specific mortality occurred for 2.2 % (54) and 13.9 % (335), respectively. After controlling for potential confounders, underweight was significantly associated with a higher risk of all-cause mortality (adjusted hazard ratio (AHR) 1.57; 95 % CI 1.26, 1.95), whereas overweight was not. When cause-specific death was considered, underweight was associated with an increased risk of either TB-specific (AHR 1.85; 95 % CI 1.03, 3.33) or non-TB-specific death (AHR 1.52; 95 % CI 1.19, 1.95) during treatment. With joint consideration of cause-specific and timing of death, underweight only significantly increased the risk of TB-specific (AHR 2.23; 95 % CI 1.09, 4.59) and non-TB-specific mortality (AHR 1.81; 95 % CI 1.29, 2.55) within the first 8 weeks of treatment. This study suggests that underweight increases the risk of early death in TB patients during treatment. | |
| dc.format.extent | 244 bytes | |
| dc.format.mimetype | text/html | |
| dc.identifier.doi | 10.1017/S0007114517003166 | |
| dc.identifier.issn | 0007-1145 | |
| dc.identifier.uri | https://ir.ntus.edu.tw/handle/987654321/65587 | |
| dc.language | en_US | |
| dc.publisher | CAMBRIDGE, ENGLAND: CAMBRIDGE UNIV PRESS | |
| dc.relation | BRITISH JOURNAL OF NUTRITION, 118(2), p1052-1060 | |
| dc.subject | Tuberculosis | |
| dc.subject | BMI | |
| dc.subject | Underweight | |
| dc.subject | Mortality | |
| dc.title | Underweight increases the risk of early death in tuberculosis patients | |
| dc.type | article | |
| dspace.entity.type | Publication |