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Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study

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cris.lastimport.scopus2026-02-25T16:01:59Z
dc.creatorChen, Yu-Yen
dc.creatorYen, Yung-Feng
dc.creatorLin, Jun-Xian
dc.creatorFeng, Shih-Chao
dc.creatorWei, Li-Chen
dc.creatorLai, Yun-Ju
dc.creatorShen, Ying-Cheng
dc.date2018
dc.date.accessioned2021-11-04T07:15:15Z
dc.date.accessioned2025-07-28T15:04:21Z
dc.date.available2021-11-04T07:15:15Z
dc.date.issued2021-11-04T07:15:15Z
dc.description.abstractPurpose. To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients. Methods. From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 2001 to 2013, a total of 22919 subjects with RVO were enrolled in the RVO group, and 114595 propensity score (PS)-matched non-RVOs were enrolled in the comparison group. PS matching was based on age, gender, obesity, diabetes, hypertension, hyperlipidemia, coronary artery disease, atrial fibrillation, hyperviscosity syndrome, Charlson comorbidity index, glaucoma, and the use of antithrombotic drugs. A multivariate Cox regression analysis was used to estimate the adjusted hazard ratios (HRs) with a 95% confidence interval (CI) for each of the clinical outcomes, including stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality. Furthermore, we divided the RVO group into the branch retinal vein occlusion (BRVO) group and the central retinal vein occlusion (CRVO) group and separately compared their subsequent risks of the clinical outcomes with those of the comparison group. Results. After adjusting for PS, the RVO group had a significantly higher risk of stroke (adjusted HR = 1.36; 95% CI: 1.32-1.40), ischemic stroke (adjusted HR = 1.36; 95% CI: 1.32-1.40), and hemorrhagic stroke (adjusted HR =1.34; 95% CI: 1.24-1.44). However, the all-cause mortality did not exhibit significant differences. Furthermore, both the BRVOs and CRVOs had a significantly higher risk of subsequent stroke, ischemic stroke, and hemorrhagic stroke than did the comparisons, whereas all-cause mortality was similar among the groups. Conclusions. People with RVO are at a significantly greater risk of developing stroke, ischemic stroke, and hemorrhagic stroke. However, RVO does not significantly increase the risk of all-cause mortality.
dc.format.extent115 bytes
dc.format.mimetypetext/html
dc.identifier.doi10.1155/2018/8629429
dc.identifier.issn2090-004X
dc.identifier.urihttps://ir.ntus.edu.tw/handle/987654321/65586
dc.languageen_US
dc.publisherLondon: HINDAWI
dc.relationJOURNAL OF OPHTHALMOLOGY, 2018
dc.subjectOPEN-ANGLE GLAUCOMA
dc.subjectBRANCH
dc.titleRisk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study
dc.typearticle
dspace.entity.typePublication

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