彽氧環境下運動視為對身體的壓力來源，進而對身體的免疫系統產生影響。補充支鏈胺基酸(branched chain amino acid ,BCAA)與碳水化合物(carbohydrate)不僅被認為對於運動表現有所影響，也可能會影響免疫反應。七名平時有運動習慣的健康成年男性，年齡25.5±0.6歲，身高168.4±1.8cm，體重69.86±2.8kg，最大攝氧量38.2±1.8ml．min-1．kg-1，隨機重覆四次實驗，分為BCAA組(攝取BCAA 12g)、CHO (攝取75g/250ml)組、BCAA+CHO (12g+75g/250ml)組、PLA(250ml)組，在低氧環境下(15% O2)休息60分鐘後，開始50%VO2max的強度90分鐘的腳踏車運動，再以85%VO2max的強度直至衰竭，休息兩個小時。分析血液中介白素-6(IL-6)，白血球(white blood cell)、淋巴球(lymphocyte)、噬中性白血球(neturophil)，可體醇(cortisol)、胰島素(insulin)，血糖(glucose)之改變。IL-6、TNF-α的濃度並無顯著改變，淋巴球在運動後BCAA+glucose組與glucose組顯著高於BCAA組(p=0.019,0.011)。本研究顯示，短期的低氧運動刺激對於血液中細胞激素並無顯著的影響，在身體周邊的免疫相關的血球數量是有增加。

　　Ingestion of carbohydrate (CHO) and branched-chain amino acids (BCAAs) before exercise might improve exercise performance. However the effects on exercise induced immune stress in hypoxia environment are still unclear. We recruited 7 health adult male( age: 25.5 ± 0.6 yrs, height: 168.4±1.8cm, weight: 69.86±2.8kg, VO2max: 38.2±1.8ml．min-1．kg-1) to participate in this study.
　　All subjects completed 4 experimental trials, BCAA (ingesting BCAAs 12g/250ml), CHO (ingesting glucose 75g/250ml), BCAA+CHO (ingesting BCAA+glucose 12g+ 75g/250ml), PLA(placebo 250ml) in a randomized order. After overnight fasting, subject were asked to ingested the test drinks and rest in the hypoxia chamber ( O2 15% ) for 60 mins before undertaking the exercise. Subjects exercised at 50%VO2 max for 90mins on a cycle ergometer, then the intensity increased to 85% VO2 max until volitional fatigue. After exercise, subjects were asked to rest for 2 hours in the hypoxia champer. Blood samples and saliva samples were collected before exercise, at 30min intervals during exercise, at fatigue, and every hour during post-exercise. Plasma samples were analyzed for IL-6 , TNF-α , cortisol, insulin, and glucose concentrations. White blood cell, lymphocyte, neturophil numbers were also measured. The results showed that there were no significant changes in plasma cytokines and saliva IgA during 4 trials. White blood cell, lymphocyte, and neturophil numbers were increased following exercise. The current results suggested ingesting CHO and BCAAs before exercise in acute hypoxia environment did not change cytokine secretion. However, the peripheral white blood cell were increased.