骨骼代謝相關基因單核甘酸多型性與其他骨質疏鬆症危險因子之研究

台灣地區30歲以上婦女骨質疏鬆的盛行率達 25%，骨質減少盛行率為 37%，且年齡越高，比例越高，停經後婦女罹患骨質疏鬆症的情形更是明顯。許多研究顯示，某些與骨骼代謝相關之基因多型性可能與罹患骨質疏鬆症的危險性有關。本研究共招募 200 名患者與 200 名對照組，均為停經後婦女，經控制其他可能危險因子後，ALU1 aa genotype 罹患骨質疏鬆症的機率較 AA 與 Aa 者顯著為高，NCOI 與 DRAII 之各 genotype 在患者與對照組之間的分布並無顯著差異。本研究所發現的 ALU1 基因多型性可能可以做為早期篩選骨質疏鬆症高危險族群，或是患者使用藥物時的參考。
The prevalence of osteoporosis in women over 30 years old was 25% in Taiwan. The prevalence of low bone mass in the same population was 37%. There is growing number of postmenopausal women suffering osteoporosis. It has been suggested that polymorphism of several genes involving in bone metabolism may be related to the risk of osteoporosis. The current study recruited 200 osteoporosis patients and 200 age-matched controls. All subjects were postmenopausal women. After controlling for other potential risk factors, ALU1 aa genotype showed significantly higher risk for osteoporosis than the other 2 genotypes. The polymorphism in NCOI and DRAII were not significantly different between the cases and controls. The results of this study may be used for screening for high risk population of osteoporosis.