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Next-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells

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cris.lastimport.scopus2026-02-27T16:02:14Z
dc.creatorChiu, Yu-Jen
dc.creatorTsai, Fuu-Jen
dc.creatorBau, Da-Tian
dc.creatorChang, Ling-Chu
dc.creatorHsieh, Min-Tsang
dc.creatorLu, Chi-Cheng
dc.creatorKuo, Sheng-Chu
dc.creatorYang, Jai-Sing
dc.date2021-07
dc.date.accessioned2021-11-08T01:36:52Z
dc.date.accessioned2025-07-27T15:03:10Z
dc.date.available2021-11-08T01:36:52Z
dc.date.issued2021-11-08T01:36:52Z
dc.description.abstractTriple-negative breast cancer (TNBC) behaves aggressively in the invasive and metastatic states. Our research group recently developed a novel curcumin derivative, (1E,3Z,6E)-3-hydroxy-5-oxohepta-1,3,6-triene-1,7-diyl)bis(2-methoxy-4,1-phenylene)bis(3-hydroxy-2-hydroxymethyl)-2-methyl propanoate (MTH-3), and previous studies showed that MTH-3 inhibits TNBC proliferation and induces apoptosis in vitro and in vivo with a superior bioavailability and absorption than curcumin. In the present study, the effects of MTH-3 on TNBC cell invasion were examined using various assays and gelatin zymography, and western blot analysis. Treatment with MTH-3 inhibited MDA-MB-231 cell invasion and migration, as shown by Transwell assay, 3D spheroid invasion assay, and wound healing assay. The results of the gelatin zymography experiments revealed that MTH-3 decreased matrix metalloproteinase-9 activity. The potential signaling pathways were revealed by next-generation sequencing analysis, antibody microarray analysis and western blot analysis. In conclusion, the results of the present study show that, MTH-3 inhibited tumor cell invasion through the MAPK/ERK/AKT signaling pathway and cell cycle regulatory cascade, providing significant information about the potential molecular mechanisms of the effects of MTH-3 on TNBC.
dc.format.extent123 bytes
dc.format.mimetypetext/html
dc.identifier.doi10.3892/or.2021.8084
dc.identifier.issn1021-335X
dc.identifier.urihttps://ir.ntus.edu.tw/handle/987654321/64469
dc.languageen_US
dc.publisherATHENS, GREECE: SPANDIDOS
dc.relationONCOLOGY REPORTS, 46(1)
dc.subjectcurcuminoid derivative
dc.subjecttriple-negative breast cancer (TNBC)
dc.subjectanti-metastasis
dc.subjectMTH-3
dc.subjectnext generation sequencing analysis
dc.titleNext-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells
dc.typearticle
dspace.entity.typePublication

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