Publication:

單次不同升糖指數飲食及運動介入對餐後脂肪代謝之影響

不健康的生活型態所導致的高血脂症與肥胖，都是造成腦血管疾病、心臟疾病、糖尿病、高血壓等疾病的原因。藉由運動及低升糖指數飲食可能可降低餐後血脂及低密度脂蛋白(LDL)上升幅度，提高高密度脂蛋白(HDL)擴清能力，進而降低罹患心血管疾病的機率。本研究探討單次運動與不同升糖指數飲食(glyemic index, GI)種類介入，對於餐後血脂的影響，並探討造成此影響的生理機轉。以無規律運動之健康男性10名為受試者(年齡: 22.9±3.0 歲; 身高: 171.9±5.6 公分; 體重: 68.2±6.2 公斤; VO2max: 52.9±4.9ml/min/kg)，採用交叉實驗設計，受試者須完成3種處置，分別為低GI (GI = 33.6, LGI)組、高GI (GI = 77.4, HGI)組、空腹(FAST)組，攝取後3小時，於跑步機進行60分鐘運動，運動強度為60%VO2max。運動後進行口服脂肪耐受度測試 (1.2 g脂肪，1.1 g碳水化合物，0.33 g蛋白質/kg 體重)，於餐後第30、90、150、210、270、330分鐘收集血液樣本，分析血漿中葡萄糖、胰島素、C胜肽、總膽固醇、LDL-C、HDL-C、三酸甘油酯、游離脂肪酸、甘油、酮體、Apo-A、Apo-B、氨、尿素氮濃度。脂肪代謝部份，3組間餐後三酸甘油酯於餐後第210分鐘及第270分鐘有顯著差異(LGI>HGI=FAST, p<0.05)。LGI組與HGI組的三酸甘油酯濃度曲線下面積無顯著差異。游離脂肪酸濃度在OFTT餐後第30分鐘及第150分鐘，空腹組顯著高於LGI組與HGI組。；3組間餐後HDL-C、葡萄糖與總膽固醇無顯著差異。研究結果顯示，相較於GI飲食，運動介入可能為較強之代謝影響因子，覆蓋單一餐不同飲食的影響，導致口服脂肪耐受度測試後脂肪代謝影響較為不明顯。

Hyperlipidemia and obesity are major risk factors for cerebral vascular disease, cardiovascular disease, diabetes, and hypertension. It has been suggested that exercise and low glycemic index diet may reduce postprandial responses in triglyceride and LDL, increase clearance capacity of HDL, and reduce the risk for cardiovascular disease. The purpose of this study was to examine the effect of different glycemic index (GI) breakfasts and subsequent exercise on postprandial lipid profile. Ten healthy active college students participated in this study (age: 22.9±3.0yrs; height: 171.9±5.6cm; weight: 68.2±6.2kg; VO2max: 52.9±4.9ml/min/kg). This study used a cross-over design. Each subject had to complete 3 trials. Subjects ingested a low GI meal (LGI, GI=33.6), a high GI meal (HGI, GI=77.4) or fast (FAST) 3 hours before running on a treadmill for 60 min at 60%VO2max. Thirty min after the exercise, subject consumed a oral fat tolerance test meal (OFTT, 1.2g/kg fat, 0.33g/kg protein, 1.1g/kg carbohydrate). Blood samples were obtained before and 30, 90, 150, 210, 270, 330 min after OFTT. Plasma concentrations of triglyceride, non-esterfied fatty acid (NEFA), total cholesterol, HDL, LDL, Insulin, C-peptide, Apo-A, Apo-B, ,NH3, blood urea nitrogen, 3-hydroxybutyrate and glucose were measured. [Triglyceride concentrations were significantly different between the 3 trials (LGI>HGI=FAST, p<0.05) at 210 min, 270 min after OFTT. The area under the curve (AUC) of Triglyceride was not significantly different in LGI compared to HGI. NEFA concentrations were significantly higher in FAST compared to HGI and LGI at 30 min and 150 min after OFTT (p<0.05). There were no significant differences in HDL, total cholesterol, and glucose concentrations after OFTT between the three trials. The results suggested that exercise may be a stronger factor than glycemic index. Therefore, exercise may cover the impact of single GI diet on postprandial lipemia after subsequent fatty meal.