長期訓練期間抗氧化酵素活性和表現量的改變及維生素E所扮演的角色(2/2)

自由基在訓練所引起的抗氧化酵素適應可能扮演著重要的角色。24 隻雄性大鼠隨機分為維生素E缺乏且運動(DE)、維生素E缺乏不運動(DNE)、維生素 E 充足且運動(AE)、維生素 E 充足且不運動(ANE)4組。在 soleus，SOD 活性與 RNA 量呈現顯著維生素 E、運動、和交互效應，同時肌肉中MDA 濃度也呈現相同的趨勢。在gastrocnemius，SOD 活性與 RNA 量呈現顯著運動效應，但 MDA 仍呈現顯著維生素E 、運動、和交互效應。 Soleus 和gastrocnemius GPX 活性在各組間均無顯著差異。本研究顯示，自由基可能參與訓練造成的肌肉中 SOD 活性的適應現象。
It has been suggested that free radicals may play a role in mediating the training-induced antioxidant enzyme changes. Twenty-four adult male rats were assigned to one of the 4 groups, vitamin E-deficient and exercise (DE), vitamin E-deficient and non-exercise (DNE), vitamin E-adequate and exercise (AE), and vitamin E-adequate and non-exercise (ANE). There were significant vitamin E, exercise and interaction effects on SOD activity and expression level in soleus. This was in parallel with MDA levels in the same muscle. In gastrocnemius, there was only exercise effect on SOD activity and RNA level, while there were still significant
vitamin E, exercise, and interaction effects on MDA levels in this muscle. GPX activities and expression levels were similar across all groups in both muscles investigated. This study suggested that exercise-induced SOD adaptation may be mediated by free radicals.