Publication: 不同的運動型態對心臟損傷之研究-以血液生化指標為研究標的
| dc.contributor.advisor | 邱彥成 | |
| dc.contributor.advisor | Chung Yen-Chen | |
| dc.creator | 吳琬真 | |
| dc.creator | Wu, Wan-Chen | |
| dc.date | 2010 | |
| dc.date.accessioned | 2017-02-27T06:37:52Z | |
| dc.date.accessioned | 2025-07-30T15:30:09Z | |
| dc.date.available | 2017-02-27T06:37:52Z | |
| dc.date.issued | 2017-02-27T06:37:52Z | |
| dc.description | 學位類別：碩士 | |
| dc.description | 校院名稱：國立台灣體育大學 | |
| dc.description | 系所名稱：運動健康科學系碩士班 | |
| dc.description | 學號：19606009 | |
| dc.description | 畢業學年度：98年 | |
| dc.description | 論文頁數：43頁 | |
| dc.description.abstract | 單車活動目前已經成為國人休閒活動的選擇之一，更有不少人為了挑戰自己的體能極限而從事長時間又中高強度的單車活動。有文獻指出，即使是專業訓練的運動選手，在經過長時間、高強度的比賽（例如：鐵人三項或是職業級單車競賽）之後，心臟損傷相關的血液生化指標濃度皆有明顯增高，代表此運動強度對選手們來說可能會造成心臟損傷；而對於未受過訓練的一般健康民眾來說，此傷害性可能會加倍提高，只是針對這方面的相關研究卻不多；因此，本研究的目的主要是在探討經由不同的運動型態活動後，觀察一般健康民眾的生理變化，評估其心臟的損傷程度及負荷程度。本研究分別從(1) 2008第三屆鐵駱駝單車環島體驗隊活動及 (2) 2008第二屆東華盃高中暨大專校園鐵人三項徵求受測者；(1)平時無運動習慣的32名(男性24名，女性8名)受測者皆完成15天總長1114公里的單車環島活動，環島期間採自由飲食及飲水。在環島活動第一天、第五天、第十天、第十五天、及結束後第四天採集血液樣本。(2) 10名平時有運動習慣的男性受測者皆完成運動項目為750公尺游泳（限時30分鐘）、20公里自行車（限時50分鐘）、5公里路跑（限時40分鐘），比賽期間無飲水限制，並在比賽前後採集血液樣本。所有血液樣本皆分析肌紅蛋白（myoglobin）、肌酸激脢MB部分（CK-MB）、N端原腦類排鈉肽胜（NT-proBNP）、心肌肌鈣蛋白（cTnT）之濃度變化。結果顯示(1) myoglobin只有在環島的第五天濃度有顯著增高，CK-MB在環島期間顯著增加；NT-proBNP在環島第五天達到最高峰，之後則是緩慢減少，並回復到基準值。(2)myoglobin比賽後濃度顯著高於比賽前，CK-MB比賽後濃度顯著高於比賽前，NT-proBNP比賽後濃度顯著高於比賽前，cTnT比賽前後濃度皆低於最小檢測值以下。研究結果顯示從事長時間的單車環島活動和鐵人三項比賽後，對於心臟損傷方面的血液生化指標濃度會隨著運動強度及時間的增加而增加，確實對心臟造成若干負荷，但很快即能恢復至原來濃度，而且變化皆在標準範圍內，至於是否真會造成心臟的損傷，亦或是這類指標有著修復心臟受損細胞的功能，仍有待進一步的研究，但一般健康民眾從事這些運動應是無太大的健康顧慮的。 | |
| dc.description.abstract | Cycling has become one of the options of leisure activities. Previous studies have demonstrated the impact of endurance exercise on cardiac damage in well-trained athletes. The effect of long-term endurance exercise on cardiac damage in untrained persons still remains unclear. The purpose of this study was to evaluate heart damage during different exercises in healthy people. These studies were achieved by: (1) 32 untrained healthy subjects (24 males and 8 females, 19-38 years old) who participated in 2008 The Ironcamel Cycling Tour of Taiwan. The tour covered 1114 km in 15 days. All subjects were in a free-feeding style during the tour. Fasting blood samples were collected in the early morning on day 1, 5, 10, 15 during the tour and 4 days after the tour. (2) 10 trained healthy males who participated in 2008 Dong Hwa University Triathlon Championships. All subjects completed for 750 meter swim (limited time : 30 minutes), 20 km bike (50 minutes), and 5 km road race (40 minutes). Water-drinking was not restricted for all subjects during the competition, and blood samples were collected before and after the race. All plasma samples were analyzed for myoglobin, creatine kinase MB (CK-MB), N-terminal B-type Natriuretic Peptide (NT-proBNP) and cardiac troponin T (cTnT) concentrations. The results showed: (1) the concentration of myoglobin was significantly increased on day 5; that of CK-MB was significantly increased during the tour; and that of NT-proBNP was peaked on day 5, then was slowly reduced and returned to baseline level . (2) myoglobin, CK-MB, and NT-proBNP levels after the race were significantly higher than before. cTnT levels were detected below the minimum before and after the race. The current results suggested that biomedical markers of heart damage might be increased according to the increase in exercise intensity and time after long-term cycling tour and triathlon, but soon returned to their original levels, changes are in the standard rage. General young people who are enjoying these kinds of activities might not have the necessity to worry about big health concerns on cardiac aspects. | |
| dc.description.tableofcontents | 目 次 第壹章 緒論……………………………………………………………1 第一節 研究背景……………………………………………………1 第二節 研究目的……………………………………………………1 第三節 研究範圍與限制……………………………………………2 第四節 研究假設……………………………………………………3 第貳章 文獻探討………………………………………………………4 第一節 運動與心臟的關係…………………………………………4 第二節 運動血液生化指標…………………………………………5 第三節 不同運動型態對心臟損傷關係之相關文獻………………9 第參章 研究方法與步驟………………………………………………11 第一節 研究對象……………………………………………………11 第二節 實驗設計……………………………………………………12 第三節 實驗流程……………………………………………………16 第四節 實驗儀器與設備……………………………………………18 第五節 血液採集與分析……………………………………………19 一、血液採集………………………………………………………19 二、血液分析與檢測項目…………………………………………21 第六節 資料處理與統計分析………………………………………22 第肆章 結果……………………………………………………………23 第一節 受試者基本資料……………………………………………23 第二節 血液生化值…………………………………………………25 第伍章 討論……………………………………………………………32 第陸章 建議……………………………………………………………35 引用文獻…………………………………………………………………36 中文文獻………………………………………………………………36 英文文獻………………………………………………………………37 | |
| dc.format.extent | 389745 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | https://ir.ntus.edu.tw/handle/987654321/71012 | |
| dc.language | zh-TW | |
| dc.publisher | 運動健康科學系碩士班 | |
| dc.relation.isbasedon | 中文文獻 王慧如、吳鴻文、李明榮、林晉利、林晉榮、張文正等(2004)。運動•休閒•健康科學─導論。台中市：鞋技中心。 呂旭峰、劉嘉又、薛樹清、施木青(2004)。檢測心臟衰竭的利器~Pro-BNP與BNP。中華民國醫檢會報，19 (5)，80-92。 陳筱婷、莊惠娟、鄭幸文(2005)。Cardiac Markers對臨床診斷應用之建議。醫檢會報，3，44-48。 劉銘恩、侯嘉殷、周友三、蔡正河(2004)。肌鈣蛋白升高之急性肺動脈栓塞：病例報告暨文獻回顧。內科學誌，15，125-129。 葉惠敏(2004)。腦類排鈉肽血清濃度對於全身麻醉病患處理的應用價值。2010年8月18日，取自國立台灣大學，醫學系麻醉科網址http://ntur.lib.ntu.edu.tw/handle/246246/28874 鄭桂玫、洪明吉(2000)。肌酸激脢對肌肉運動傷害評估探討。大專體育，49，189-193。 英文文獻 Adam, J., & Apple, F. (2004). New blood tests for detecting heart disease. Circulation, 109, e12-e14. Cleave, P., Boswell, T. D., Speedly, D. B., & Boswell, D. R. (2001). Plasma cardiac troponin concentrations after extreme exercise. Clinical Chemistry, 47, 608-610. Serrano-Ostáriz, E., Legaz-Arrese, A., Terreros-Blanco, J. L., López-Ramón, M., Cremades-Arroyos, D., & Álvarez-Izquierdo, S., et al. (2009). Cardiac Biomarkers and exercise duration and intensity during a cycle-touring event. Clinical Journal of Sport Medicine, 19(4), 293-299. Huang, W. S., Lee, M. S., Perng, H. W., Yang, S. P., Kuo, S. W., & Chang, H. D. (2002). Circulating brain natriuretic peptide values in healthy men before and after exercise. Metabolism, 51(11), 1423-1426. Lewandrowski, K., Chen, A., & Januzzi, J. (2002). Cardiac markers for myocardial infarction. American Journal of Clinical Pathology, 118(Suppl 1), S93-S99. König, D., Schumacher, Y. O., Heinrich, L., Schmid, A., Berg, A., & Dickhuth, H.-H. (2003). Myocardial stress after competitive exercise in professional road cyclists. Medicine and Science in Sports and Exercise, 35(10), 1679-1683. Gerche, A. L., Boyle, A., Wilson, A. M., & Prior, D. L. (2004). No evidence of sustained myocardial injury following an ironman distance triathlon. International Journal of Sports Medicine, 25(1), 45-49. Mair, J., & Puschendorf, B. (1995). Current aspects in the laboratory diagnosis of acute myocardial infarction. Labmedicine, 19, 304-318. Niemelä, K. O., Palatsi, I. J., Ikäheimo, M. J., Takkunen, J. T., & Vuori, J. J. (1984). Evidence of impaired left ventricular performance after an uninterrupted competitive 24 hour run. Circulation, 70(3), 350-356. Neilan, T. G., Januzzi, J. L., Lewanrowski, E. L., Ton-Nu, T. T., Yoerger, D. M., & Jassal, D. S., et al. (2006). Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation, 114, 2325-2333. Neumayr, G., Gaenzer, H., Pfister, R., Sturm, W., Schwarzacher, S. P., & Eibl, G., et al. (2001). Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise. The American Journal Cardiology, 87(3), 369-371, A10. Ohba, H., Takada, H., Musha, H., Nagashima, J., Mori, N., & Awaya, T., et al. (2001). Effect of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men. The American Heart Journal, 141, 751-758. Reiffert, S., Jaquet, K., Helimeyer, L., & Herberg, F. (1998). Stepwise subunit interaction changes by mono and bisphosphorylation of cardiac troponi I. Biochemistry, 37, 13516-13525. Rifai, N., Douglas, P. S., O’Toole, M., Rimm, E., & Ginsburg, G. S. (1999). Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. The American Journal Cardiology, 15(7), 1085-1089. Scharhag, J., Herrmann, M., Urhausen, A., Haschke, M., Herrmann, W., & Kindermann, W. (2005). Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged streuous exercise. The American Heart Journal, 150, 1128-1134. Scharhag, J., George, K., Shave, R., Urhausen, A., & Kindermann, W. (2008). Exercise-associates increases in cardiac biomarkers. Medicine and Science in Sports and Exercise, 40(8), 1408-1415. Powers, S. K., & Howley, E. T. (2004). Exercise Physiology: Theory and Application to Fitness and Performance, Fifth Edition. New York, IL: McGraw-Hill. Shave, R., Dawson, E., Whyte, G., George, K., Ball, D., & Gaze, D.et al. (2002).Evidence of exercise-induced cardiac dysfunction and elevated cTnT in separate cohorts competing in an ultra-endurance mountain marathon race. International Journal of Sports Medicine, 23(7), 489-494. Shave, R., Dawson, E., Whyte, G., George, K., Ball, D., & Gaze, D., et al. (2003). Cardiac troponin T in female athletes during a two-day mountain marathon. Strategic Management Journal, 48(2), 41-42. Shave, R., Dawson, E., Whyte, G., George, K., Gaze, D., & Collinson, P. (2004). Effect of prolonged exercise in a hypoxic environment on cardiac function and cardiac troponin T. British Journal of Sports Medicine, 38, 86-88. Shave, R., Dawson, E., Whyte, G., George, K., Gaze, D., & Collinson, P. (2004). Altered cardiac function and minimal cardiac damage during prolonged exercise. Medicine and Science in Sports and Exercise, 36(7), 1098-1103. Shave, R., Dawson, E., Whyte, G., George, K., Ball, D., & Collinson, P., et al. (2002). The cardiospecificity of the third-generation cTnT assay after exercise-induced muscle damage. Medicine and Science in Sports and Exercise, 34(4), 651-654. Takashima, W., Ishii, K., Takizawa, K., Yamaguchi, T., & Nosaka, K. (2007). Muscle damage and soreness following a 50- km cross-country ski race. European Journal of Sport Science, 7(1), 27-33. Whyte, G. P., George, K., Sharma, S., Lumley, S., Gates, P., & Prasad, K., et al. (2000). Cardiac fatigue following prolonged endurance exercise of differing distances. Medicine and Science in Sports and Exercise, 32(6), 1067-1072. | |
| dc.subject | 長途單車活動;鐵人三項;心臟損傷;生化指標 | |
| dc.subject | long-term cycling;triathlon;heart damage;biomedical markers | |
| dc.title | 不同的運動型態對心臟損傷之研究-以血液生化指標為研究標的 | |
| dc.title | HEART DAMAGE DURING DIFFERENT EXERCISE-USING BLOOD BIOMEDICAL MARKERS | |
| dc.type | thesis | |
| dspace.entity.type | Publication |
Files
Original bundle
1 - 1 of 1