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Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

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cris.lastimport.scopus2026-03-01T16:01:57Z
dc.contributorNational Taiwan University of Sport
dc.creatorLan, Chieh-Yu
dc.creatorChen, Sheng-Yi
dc.creatorKuo, Chia-Wen
dc.creatorLu, Chi-Cheng
dc.creatorYen, Gow-Chin
dc.date2019-10
dc.date.accessioned2021-10-30T07:42:22Z
dc.date.accessioned2025-07-27T15:02:32Z
dc.date.available2021-10-30T07:42:22Z
dc.date.issued2021-10-30T07:42:22Z
dc.description.abstractThe triggering of gemcitabine (GEM) drug resistance in pancreatic cancer by the receptor for advanced glycation end products (RAGE) has been demonstrated. Hence, finding a safe and effective adjuvant for preventing pancreatic cancer progression is imperative. Quercetin is a flavonoid that is abundant in apples, grapes, red raspberry, and onions and has been reported to inhibit RAGE. This research aimed to investigate the mechanisms of quercetin in regulating cell death and enhancing drug effects through RAGE reduction, especially in GEM-resistant pancreatic cancer cells. Our results showed that silencing RAGE expression by RAGE-specific siRNA transfection significantly increased cell death by apoptosis, autophagy and GEM-induced cytotoxicity by suppressing the PI3K/AKT/mTOR axis in MIA Paca-2 and MIA Paca-2 (GEMR) cells (GEM-resistant cells). Notably, quercetin showed a dramatic effect similar to RAGE silencing that effectively attenuated RAGE expression to facilitate cell cycle arrest, autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 GEMR cells, suggesting that an additional reaction occurred under combined quercetin and GEM treatment. In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression. Copyright (C) 2019, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
dc.format.extent142 bytes
dc.format.mimetypetext/html
dc.identifier.doi10.1016/j.jfda.2019.07.001
dc.identifier.issn1021-9498
dc.identifier.urihttps://ir.ntus.edu.tw/handle/987654321/64410
dc.languageen_US
dc.publisherBERKELEY, CA: DIGITAL COMMONS BEPRESS
dc.relationJOURNAL OF FOOD AND DRUG ANALYSIS, 27(4), p.887-896
dc.subjectAutophagy
dc.subjectGemcitabine resistance
dc.subjectPancreatic cancer
dc.subjectQuercetin
dc.subjectRAGE
dc.titleQuercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
dc.typearticle
dspace.entity.typePublication

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