Publication:

不同碳水化合物與運動介入對餐後脂肪代謝相關基因之影響

許多學者認為發現餐後高血脂會提高罹患心血管疾病的風險，因此降低餐後血脂可能可以減少罹患心血管疾病風險。本篇研究將探討補充果糖或葡萄糖飲品後運動或休息一小時，再給予高脂肪餐點，觀察6小時餐後血脂代謝的變化；並檢測血脂代謝相關的基因表現，以更了解不同碳水化合物與運動影響餐後血脂代謝的機轉。本實驗為8名有規律運動的健康男性受測者，所有受測者須以隨機的方式完成4組實驗，分別為:75克葡萄糖組（G）、75克果糖組（F）、75克葡萄糖加運動組（G+ EX）、75克果糖加運動組（F+ EX），運動組以強度為60% VO2max跑步1小時，休息組則必須安靜休息，運動或休息1小時後立即給予高脂肪餐點。本研究主要結果在血漿中生化值的部份，四組都沒有顯著差異，補充果糖有較高的血漿ApoA-I，血漿中TC、LDL-C則都低於補充葡萄糖組別， ApoA-I、Apo B、LDLR、HMGCR、VLDLR基因表現沒有顯著的影響，但是補充果糖有降低VLDLR基因表現的趨勢。本研究的結果顯示不同碳水化合物與運動介入對餐後血脂代謝相關基因的影響並不大。

Postprandial hyperlipemia increases the risk of cardiovascular diseases. Strategies to reduce postprandial lipemia might lower the risk of cardiovascular diseases. The purpose of this study was to investigate the effect of carbohydrate and exercise on lipid metabolism related gene expression after high fat meal. Eight healthy, active male subjects completed 4 experimental trials in a randomized order and cross-over design. After overnight fast, subjects either ingested 75 g fructose (F) or 75 g glucose (G) and rest or exercise at 60% VO2max for 1 hour (F+EX, G+EX) before an oral fat tolerance test. Blood samples were collected during 6 hour postprandial period. The results showed that F and F+EX induced higher plasma ApoA-I and lower plasma total cholesterol and LDL-C than G and G+EX. There were no significantly differences in ApoA-I、Apo B、LDLR、HMGCR、VLDLR gene expression between trials. However, there was a trend that ingesting fructose group indicated a lower VLDLR gene expression. The current data suggested that ingestion of different carbohydrates and exercise before a high fat challenge did not influence postprandial lipid metabolism related gene expression.