Purpose: To compare the effects of intense endurance and strength exercises on the blood lactate and serum immunoglobulin concentration between athletes and non-athletes. Methods: There were 9 athletes with average age 18.89±0.60 yrs, height 165.22±4.35 cm, weight 51.67±4.12 kg, and VO2max 54.07±2.20 ml•kg-1•min-1. The other 9 non-athletes with average age 19.11±0.33 yrs, height 158.33±3.81 cm, weight 51.33±6.32 kg, and VO2max 36.54±3.65 ml•kg-1•min-1. Subjects were asked to perform both intense endurance and strength exercises (running on a treadmill until exhausted and knee extension and flexion on a Kin-Com until fatigue, respectively). Blood samples were collected both before and after exercises. The data was analyzed by the two- factorial ANOVA and pearson product-moment correlation coefficient. Results: The VO2max and peak torque of athletes were significantly higher than non -athletes (p＜.05). The blood lactate of both groups was significantly increased after different exercises (p＜.05). The serum immunoglobulin was significantly increased in athletes after the intense endurance exercise (p＜.05), but was no significant difference in non-athletes. There was no significant difference before and after strength exercise for both groups. There was no significant correlation in the variety of blood lactate and serum immunoglobulin before and after different exercises for both groups. Conclusions: The concentration of immunoglobulin of serum would be enhanced after the athlete did the intense endurance exercise. It needs further study to know whether it is related to the fact of long-term regular exercise training. There was no significant relationship between blood lactate and serum immunoglobulin (IgG, IgA, IgM) before and after exercise.